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Recent research has found out that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent have a very particular mutation that creates them prone to benefit from naltrexone, weighed against about 20% of Caucasians and less than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director in the UCLA Addictions Laboratory. The findings are presently available online ( inside the journal Neuropsychopharmacology and are published in an upcoming print edition with the journal. Using two separate drugs to shed weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err assisting caution and allow FDA do its job and demand some research be done in order that the public understands the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say anything to keep people on his or her medications. Researchers found out that participants using this drug for the year, dropped a few pounds within 4 weeks and have kept the weight off throughout the 56 weeks from the study. Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of multiple active ingredient, which might make them more effective and safer. Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there are not any long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug may also raise hypertension and pulse rate, and mustn't be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not be used in patients with uncontrolled high hypertension, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients to the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. From a psychiatric viewpoint, evidence points too the ordinary neural mechanism for goal-directed behavior continues to be hijacked by the addiction, and malfunctions in a way that its ordinary functions are exaggerated and fixated on its object. An object produces a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).